IMR Press / FBL / Volume 22 / Issue 10 / DOI: 10.2741/4572

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

NOK mediates glycolysis and nuclear PDC associated histone acetylation

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1 Department of Microbiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
2 State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing 100071, China
3 National Key Laboratory of Medical Molecular Biology and Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China
4 Department of Radiation Oncology, Weill Medical College of Cornell University, New York, New York 10065, USA

Academic Editors: Nevim Aygun, Siamak Tabibzadeh

Front. Biosci. (Landmark Ed) 2017, 22(10), 1792–1804; https://doi.org/10.2741/4572
Published: 1 March 2017
Abstract

NOK is a potent oncogene that can transform normal cells to cancer cells. We hypothesized that NOK might impact cancer cell metabolism and histone acetylation. We show that NOK localizes in the mitochondria, and while it minimally impacts tricarboxylic acid (TCA) cycle, it markedly inhibits the process of electron transport and oxidative phosphorylation processes and dramatically enhances aerobic glycolysis in cancer cells. NOK promotes the mitochondrial-nuclear translocation of pyruvate dehydrogenase complex (PDC), and enhances histone acetylation in the nucleus. Together, these findings show that NOK mediates glycolysis and nuclear PDC associated histone acetylation.

Keywords
RPTK
NOK
Warburg Effect
Aerobic Glycolysis
Mitochondria-Nucleus Translocation
Mitochondria
acetyl-CoA
Acetylation
Histone
Pyruvate Dehydrogenase Complex
Tricarboxylic Acid Cycle
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