IMR Press / FBL / Volume 21 / Issue 6 / DOI: 10.2741/4456

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Role of exosomes in the reproductive tract Oviductosomes mediate interactions of oviductal secretion with gametes/early embryo

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1 Department of Biology, College of Medicine, University of Dammam (UOD), P. O. Box 2435 Dammam, 31451, Saudi Arabia
2 Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Academic Editor:Patricia Anastasia Martin-DeLeon
Front. Biosci. (Landmark Ed) 2016, 21(6), 1278–1285; https://doi.org/10.2741/4456
Published: 1 June 2016
(This article belongs to the Special Issue Exosomes: their role in the reproductive tracts)
Abstract

The oviductal epithelial membrane releases into the luminal environment extracellular vesicles (EVs) which are pleomorphic in nature and fall into two categories: exosomes and microvesicles. Both of these membrane vesicles are referred to as Oviductosomes (OVS), and to date have been identified in the murine and bovine species. Bovine EVs derived in vivo and from in vitro culture show differences in their protein cargo which includes CD9 and HSC70 biochemical markers and fertility-modulating proteins such as oviduct-specific glycoprotein (OVGP) and Plasma Membrane Ca2+ ATPase 4 (PMCA4). PMCA4, an essential multifunctional sperm protein, is hormonally-regulated with elevated levels seen in proestrus/estrus. OVS deliver PMCA4 to sperm via a fusogenic mechanism involving the interaction between CD9 and integrins which are present on their surfaces. Studies of OVS are needed to determine the components of their cargoes and their interaction with oocytes and the very early embryo. Based on our present knowledge of their interaction with sperm, they are expected to play pivotal roles in regulating fertility and promise to inform the current IVF practice.

Keywords
Oviductosomes
PMCA4
Capacitation
Acrosome Reaction
Fusion
Fertility
Review
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