IMR Press / FBL / Volume 21 / Issue 6 / DOI: 10.2741/4451

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Photo-thermal therapy of bladder cancer with Anti-EGFR antibody conjugated gold nanoparticles

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1 Institute of BioMedical Engineering, National Cheng Kung University, Tainan, Taiwan
2 Department of Urology, China Medical University Beigang Hospital, Yunlin, Taiwan
Front. Biosci. (Landmark Ed) 2016, 21(6), 1211–1221; https://doi.org/10.2741/4451
Published: 1 June 2016
Abstract

The aim of this study was to enhance the effectiveness of photo thermal therapy (PTT) in the targeting of superficial bladder cancers using a green light laser in conjunction with gold nanoparticles (GNPs) conjugated to antibody fragments (anti-EGFR). GNPs conjugated with anti-EGFR-antibody fragments were used as probes in the targeting of tumor cells and then exposed to a green laser (532nm), resulting in the production of sufficient thermal energy to kill urothelial carcinomas both in vitro and in vivo. Nanoparticles conjugated with antibody fragments are capable of damaging cancer cells even at relatively very low energy levels, while non-conjugated nanoparticles would require an energy level of 3 times under the same conditions. The lower energy required by the nanoparticles allows this method to destroy cancerous cells while preserving normal cells when applied in vivo. Nanoparticles conjugated with antibody fragments (anti-EGFR) require less than half the energy of non-conjugated nanoparticles to kill cancer cells. In an orthotopic bladder cancer model, the group treated using PTT presented significant differences in tumor development.

Keywords
Photothermal Therapy
Gold Nanoparticles
Urothelial Cancer
Target Therapy
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