IMR Press / FBL / Volume 21 / Issue 4 / DOI: 10.2741/4421

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Optogenetic user’s guide to Opto-GPCRs

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1 Institute for Physiology, University of Bern, Switzerland
Academic Editors:Nevim Aygun, Siamak Tabibzadeh
Front. Biosci. (Landmark Ed) 2016, 21(4), 794–805; https://doi.org/10.2741/4421
Published: 1 January 2016
Abstract

Optogenetics has taken biomedical research by storm. The power and precision at which light-gated ion channels control cellular excitability in diverse biological systems has convinced researchers of an optical future. Growing interest in optical methods has sparked the development of multiple new optogenetic tools, which allow precise control of numerous cellular processes. Among these new tools are the light-activatable G-protein coupled receptors (GPCRs) or Opto-GPCRs. The extent of the GPCR family, which in humans alone encompasses approximately 800 different proteins, and the immense therapeutic potential of Opto-GPCRs predict a big future for this juvenile field. Here the different approaches taken to design Opto-GPCRs are reviewed, outlining the advantages and disadvantages of each method for physiological and potential clinical application.

Keywords
G-Protein Coupled Receptors
Optogenetics
Protein Engineering
Opsin
Signal Transduction
G-Protein Specificity
Designer Optogenetic Tools
Chimeric G-Protein Coupled Receptors
Review
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