IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4381

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Heat shock proteins in main pediatric malignancies. A clinical overview

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1 Department of Medical Chemistry, Medical University of Gdansk, Gdansk 80-211, Debinki 1 Street, Poland
2 Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk 80-952, Debinki 7 Street, Poland
Academic Editors:Magdalena Anna Karas, Anna Turska-Szewczuk
Front. Biosci. (Landmark Ed) 2016, 21(1), 157–164; https://doi.org/10.2741/4381
Published: 1 January 2016
Abstract

Heat shock proteins belong to a group of molecular chaperones responsible for the regulation of many intracellular processes. HSPs play a pivotal role in the survival of cells under stressful conditions. Over-expression of these proteins have been found in both healthy and a great number of cancer cells. HSPs may be involved in numerous carcinogenic and chemoresistant processes. Due to that fact, they may be referred to as diagnostic biomarkers of oncogenesis and potential targets for anticancer drugs. Thus, we decided to review the involvement of major HSPs in the most malignant childhood cancers.

Keywords
Heat Shock Proteins
Cancer
Leukemia
Osteosarcoma
Neuroblastoma
Medulloblastoma
Review
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