IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4379

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Molecular mechanisms in differentiated thyroid cancer

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1 Center of Thyroid and Parathyroid, Department of General Surgery, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University of Medicine, Shanghai, China
2 Department of Nuclear Medicine, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai, China
3 Institute of Intervention Vessel, Tongji University, North Zhongshan Road, Shanghai, China
Front. Biosci. (Landmark Ed) 2016, 21(1), 119–129;
Published: 1 January 2016
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)

Thyroid cancer is a common endocrine malignancy. The tumorigenesis of thyroid tumours has been identified in recent years, including numerous genetic alterations and several major signalling pathways. However, the molecular mechanisms involved in thyroid cancer metastasis remain controversial. Studies in thyroid cancer metastasis suggested that reactivation of several pathways, including epithelial to mesenchymal transition and microenvironment change, may be involved in thyroid cancer migration. The previously identified thyroid oncogenes, BRAF, RET/PTC and Ras, play important roles in regulating the metastatic process. Here, we review the recent knowledge eon molecular mechanisms involved in thyroid cancer metastasis.

hyroid Cancer
Lymphaticand Distant Metastasis
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