IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4374

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Role of the tumor microenvironment in pancreatic adenocarcinoma

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1 Interventional Center, TongRen Hospital affiliated to Shanghai Jiaotong University School of Medicine, No. 786, Yuyuan Road, Shanghai 200050, China
2 Institute of Medical Intervention Engineering, Tongji University, North Zhongshan Road, Shanghai, China
Front. Biosci. (Landmark Ed) 2016, 21(1), 31–41;
Published: 1 January 2016
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)

Pancreatic cancer is a devastating disease with proclivity for early metastasis, which accounts for its poor prognosis. The clinical problem of pancreatic cancer is its resistance to conventional therapies, such as chemotherapy or radiation. Based upon these challenges, the focus of research on pancreatic cancer has shifted gradually towards the tumor microenvironment. The cancer microenvironment consists of various components, including fibroblasts, endothelial cells, immune cells, and endocrine cells, that interact with each other, and with the cancer cells in a complex fashion. Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells, to improve the prognosis of the disease. In the present review, we describe the cellular microenvironment of pancreatic ductal adenocarcinoma (PDA), the major type of pancreatic cancer. Our hope is that a better understanding of the cellular microenvironment of PDA will eventually lead to better treatments for this disease.

Tumor Microenvironment
Cellular Components
Pancreatic Ductal Adenocarcinoma
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