IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4371

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The role of microRNAs in the pathogenesis of pituitary tumors

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1 Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Academic Editor:Xu Jin
Front. Biosci. (Landmark Ed) 2016, 21(1), 1–7; https://doi.org/10.2741/4371
Published: 1 January 2016
(This article belongs to the Special Issue The dual role of ERK signaling in the apoptosis of neurons)
Abstract

Pituitary tumors, the most common intracranial tumors, lead to serious morbidity through the inappropriate secretion of pituitary hormones. The anomalous expression of microRNAs (miRNAs), which have a crucial status in the development and function of pituitary gland, promotes the tumorigenesis of hypothalamic–pituitary axis-related pituitary tumors. This mainly leads to alterations in the function of the hypothalamic–pituitary–adrenal axis, hypothalamic–pituitary–gonadal axis and hypothalamic–pituitary–growth hormone. In the tumorigenesis of pituitary tumors, miRNAs have complex roles. They can induce cell cycle arrest, inhibiting cell proliferation and inducing apoptosis via different pathways; however, they also promote the occurrence of pituitary tumors through direct interactions with transcription factors. This review summarizes recent progress in the study of miRNAs on the pathogenesis of pituitary tumors

Keywords
MicroRNAs
Adrenocorticotropic hormone
Let-7
Review
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