IMR Press / FBL / Volume 20 / Issue 8 / DOI: 10.2741/4369

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
ALK-mediated post-transcriptional regulation: focus on RNA-binding proteins
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1 Institut de Recherches Cliniques de Montreal (IRCM), Montreal H2W1R7, QC, Canada
2 Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
3 Centre de Biologie du Developpement (CBD), Universite Toulouse III, CNRS, UMR5547, 31062 Toulouse, France, presently at Museum d’Histoire Naturelle, 31000 Toulouse, France
4 Inserm, UMR1037 CRCT, F-31000 Toulouse, France
5 Universite Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000 Toulouse, France
6 CNRS, ERL5294 CRCT, F-31000 Toulouse, France
7 European Research Initiative on ALK-related malignancies (ERIA)
Academic Editor:Roberto Chiarle
Front. Biosci. (Landmark Ed) 2015, 20(8), 1250–1258; https://doi.org/10.2741/4369
Published: 1 June 2015
(This article belongs to the Special Issue ALK: 20 years of discoveries)
Abstract

Extensive research has been carried out in the past two decades to provide insights into the molecular mechanisms by which the Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK) exerts its oncogenic effects. These studies led to the concept that NPM-ALK acts at the transcriptional level through the activation of several transcription factors downstream of many different signaling pathways including JAK3/STAT3, PI3K/AKT and RAS/ERK. Nevertheless, the discovery of several RNA-binding proteins (RBPs) within ALK interactome suggested an additional and complementary role of this oncogenic kinase at the post-transcriptional level. This review gives emerging views in ALK-mediated post-transcriptional regulation with a focus on RBPs that are associated with ALK. We will summarize the capacity of NPM-ALK in modulating the biological properties of RBPs and then discuss the role of cytoplasmic aggregates, called AGs for “ALK granules”, which are observed in anaplastic large cell lymphoma (ALCL) expressing the ALK kinase. AGs contain polyadenylated mRNAs and numerous RBPs but are distinct from processing bodies (PBs) and stress granules (SGs), two well-known discrete cytoplasmic sites involved in mRNA fate.

Keywords
ALCL
NPM-ALK
Post-transcriptional regulation
RBPs
Review
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