IMR Press / FBL / Volume 20 / Issue 7 / DOI: 10.2741/4356

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Identification of biomarkers for bone union promoted by mechanical stimulation
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1 Department of Orthopedic Surgery, Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2015, 20(7), 1036–1046; https://doi.org/10.2741/4356
Published: 1 June 2015
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

At present, the identity of the proteins that participate in mechanical stimulation during the fracture healing process is not known. Here, we screened for and identified 299 proteins that are expressed in various stages of mechanically stimulated fracture healing. Among these biomarkers, 54 proteins were differentially expressed during all three recovery time points. Gene ontology (GO) analysis and selected biomarker candidates were used to determine their involvement in biological processes required for mechanically stimulated healing. The levels of cofilin-1 and A2HSG protein were significantly upregulated in the forth week after fracture suggesting that that they play a role in mechanically stimulated fracture healing.

Keywords
iTRAQ
Mechanical Stimulation
Fracture Healing
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