IMR Press / FBL / Volume 20 / Issue 4 / DOI: 10.2741/4335

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Prediction of clinical outcome in severe traumatic brain injury
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1 Department of neurosurgery, shanghai tenth people hospital, tongji university, 301yanchang road shanghai P.R. China 200072
2 Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Academic Editor:Xu Jin
Front. Biosci. (Landmark Ed) 2015, 20(4), 763–771;
Published: 1 January 2015
(This article belongs to the Special Issue The dual role of ERK signaling in the apoptosis of neurons)

Traumatic brain injury (TBI) is the main cause of death and disability in adults worldwide. Early detection of TBI would be useful for evaluating and designing treatment strategies. Both single predictors from early clinical examination and multiple hospitalization variables/parameters can be used to determine the long-term prognosis of TBI. Predictive models like the IMPACT or CRASH prognosis calculator (based on large sample sizes) can predict mortality and unfavorable outcomes. Moreover, imaging techniques like MRI (Magnetic Resonance Imaging) can also predict consciousness recovery and mental recovery in severe TBI, while biomarkers associated with stress correlate with, and hence can be used to predict, severity and mortality. All predictors have limitations in clinical application. Further studies comparing different predictors and models are required to resolve limitations of current predictors.

Traumatic brain injury
Magnetic Resonance Imaging
Traumatic Brain Injury
somatosensory evoked potential
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