IMR Press / FBL / Volume 20 / Issue 2 / DOI: 10.2741/4311

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism
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1 Department of Demyelinating disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187-8502, Japan
2 Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
Academic Editor:Tatsuro Mutoh
Front. Biosci. (Landmark Ed) 2015, 20(2), 314–324; https://doi.org/10.2741/4311
Published: 1 January 2015
Abstract

Cerebral accumulation of amyloid β-protein (Ab) is thought to play a key role in the molecular pathology of Alzheimer’s disease (AD). Three secretases (β-, γ-, and α-secretase) are proteases that control the production of Aβ from amyloid precursor protein. Increasing evidence suggests that cholesterol-rich membrane microdomains termed ‘lipid rafts’ are involved in the biogenesis and accumulation of Aβ as well as Aβ-mediated neurotoxicity. γ-Secretase is enriched in lipid rafts, which are considered an important site for Aβ generation. Additionally, Aβ-degrading peptidases located in lipid rafts, such as neprilysin, appear to play a role in Aβ catabolism. This mini-review focuses on the roles of lipid rafts in the biogenesis and catabolism of Aβ, covering recent research on the relationship between lipid rafts and the three secretases or Aβ-degrading peptidases. Furthermore, the significance of lipid rafts in Aβ aggregation and neurotoxicity is briefly summarized.

Keywords
Alzheimer’s Disease
Amyloid β-Protein
ADAM10
BACE1
cholesterol
γ-Secretase
Lipid Rafts
Neprilysin
Review
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