IMR Press / FBL / Volume 20 / Issue 2 / DOI: 10.2741/4310

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Lipid rafts and their possible involvements in neuroimmunological disorders: new research arena
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1 Department of Neurology, Fujita Health University, Toyoake, Japan
Academic Editor:Tatsuro Mutoh
Front. Biosci. (Landmark Ed) 2015, 20(2), 303–313; https://doi.org/10.2741/4310
Published: 1 January 2015
Abstract

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are presumed to be an autoimmune disease in the central nervous system (CNS). Although lipids are most abundant components in the nervous system, it has been believed that cellular and/or humoral immunity to various myelin proteins causes these neuroinflammatory diseases. Recent research advances enable us to study lipids in the membranes and some key molecules involved in various neurological disorders including Guillain–Barré syndrome, Alzheimer’s disease, Parkinson’s disease, and prion disease, are localized in lipid rafts. In MS and NMO, the key molecules for the pathogenesis or the target molecules for the treatments of MS and NMO are also localized in lipid rafts. Here in this article, we highlight on the possible involvement of lipid rafts in the pathogenesis and treatment of MS and NMO and introduce our recent observation of aquaporin 4 regarding NMO.

Keywords
Lipid Rafts
Multiple Sclerosis
Neuromyelitis Optica
Review
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