IMR Press / FBL / Volume 20 / Issue 2 / DOI: 10.2741/4306

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Morphological control of mitochondrial bioenergetics
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1 Department of Physiology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
Academic Editor:Robert William Gilkerson
Front. Biosci. (Landmark Ed) 2015, 20(2), 229–246; https://doi.org/10.2741/4306
Published: 1 January 2015
(This article belongs to the Special Issue Mitochondrial bioenergetics in human health)
Abstract

The major function of mitochondria is production and supply of cellular energy. Mitochondria are highly dynamic organelles undergoing frequent shape changes via fission and fusion. Many studies have elucidated the molecular components mediating fission and fusion and their regulatory mechanisms, and mitochondrial shape change is now recognized as an essential cellular process that is closely associated with functional states of mitochondria. This review updates the recent advancements in fission and fusion mechanisms, and discusses the bi-directional relationship between mitochondrial morphology and energetic states in physio-pathological settings.

Keywords
Mitochondria
Fission
Fusion
Morphology
Dynamics
DLP1
Drp1
Mfn
OPA1
Bioenergetics
Review
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