IMR Press / FBL / Volume 20 / Issue 1 / DOI: 10.2741/4297

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Post-transcriptional inducible gene regulation by natural antisense RNA

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1 Laboratory of Medical Chemistry, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan
2 Laboratory of Pharmacognosy, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan
3 Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, Japan
4 Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan
5 Laboratory of Microbiology and Cell Biology, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan
Academic Editor:Tominori Kimura
Front. Biosci. (Landmark Ed) 2015, 20(1), 1–36;
Published: 1 January 2015
(This article belongs to the Special Issue Regulatory long non-coding RNA)

Accumulating data indicate the existence of natural antisense transcripts (asRNAs), frequently transcribed from eukaryotic genes and do not encode proteins in many cases. However, their importance has been overlooked due to their heterogeneity, low expression level, and unknown function. Genes induced in responses to various stimuli are transcriptionally regulated by the activation of a gene promoter and post-transcriptionally regulated by controlling mRNA stability and translatability. A low-copy-number asRNA may post-transcriptionally regulate gene expression with cis-controlling elements on the mRNA. The asRNA itself may act as regulatory RNA in concert with trans-acting factors, including various RNA-binding proteins that bind to cis-controlling elements, microRNAs, and drugs. A novel mechanism that regulates mRNA stability includes the interaction of asRNA with mRNA by hybridization to loops in secondary structures. Furthermore, recent studies have shown that the functional network of mRNAs, asRNAs, and microRNAs finely tunes the levels of mRNA expression. The post-transcriptional mechanisms via these RNA–RNA interactions may play pivotal roles to regulate inducible gene expression and present the possibility of the involvement of asRNAs in various diseases.

Natural Antisense Transcript
mRNA Stability
Secondary Structure
NonCoding RNA
Herbal Medicine
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