IMR Press / FBL / Volume 2 / Issue 4 / DOI: 10.2741/A178

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Fibronectin-integrin interactions
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1 Department of Medical and Physiological Chemistry, The Biomedical Center, Box 575, S-751 23 Uppsala, Sweden. staffan.johansson@bmc.uu.se
Academic Editor:Staffan Johansson
Front. Biosci. (Landmark Ed) 1997, 2(4), 126–146; https://doi.org/10.2741/A178
Published: 1 March 1997
(This article belongs to the Special Issue Integrins, cell migration and extracellular matrix)
Abstract

Fibronectin is recognized by at least ten cell surface receptors of the integrin family. Most cell types in the body can adhere to fibronectin via these receptors, and thereby fibronectin becomes involved in many different biological processes. Three areas related to fibronectin and its receptors which have developed rapidly during the last few years are summarized in this review: the mechanisms of interactions between fibronectin and integrins, fibronectin polymerization, and in vivo functions of the proteins as studied by gene targeting in mice.

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