IMR Press / FBL / Volume 18 / Issue 4 / DOI: 10.2741/4180

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer

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1 Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy
2 Department of Experimental Medicine, University of Rome Sapienza, Rome, Italy
3 Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
4 Department of Biology, Piemonte Orientale University, Alessandria, Italy
5 Department of Drug Sciences, Section of Biochemistry, University of Catania, Catania, Italy
Front. Biosci. (Landmark Ed) 2013, 18(4), 1290–1310;
Published: 1 June 2013

Carcinogenesis is a multi-step process triggered by cumulative genetic alterations, which drive the progressive transformation of a normal cell into a cancer cell. Among the signal transduction pathways whose crosstalk plays an important role in neoplastic transformation are those mediated by ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) cascade. Polyphenols can be employed to inhibit the growth of cancer cells due to their ability to modulate the activity of multiple targets involved in carcinogenesis through simultaneous direct interaction or modulation of gene expression. This review will describe the cross-talk between ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) signaling pathways and the potential role of polyphenols in inhibiting this dialogue and the growth of cancer cells.

ErbB receptor
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