IMR Press / FBL / Volume 18 / Issue 3 / DOI: 10.2741/4144

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

microRNAs in gastric cancer invasion and metastasis
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1 Department of Gastrointestinal Surgery, Gansu Tumor Hospital, Lanzhou, Gansu 730050, P.R. China
Front. Biosci. (Landmark Ed) 2013, 18(3), 803–810;
Published: 1 June 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)

microRNAs (miRNAs) are fundamental gene regulators that can control cell proliferation, differentiation, and apoptosis during tumor development. These molecules can function as oncogenes or tumor suppressors in human cancers. In gastric cancer (GC), miRNAs play a dual role of either promoting or inhibiting cancer invasion and metastasis. In addition, some miRNAs are involved in only the invasion or metastasis, while other miRNAs have multiple functions and participate in invasion, migration and metastasis. In this review, we will discuss the role of miRNAs in the invasion and metastasis of GC.

Gastric Cancer
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