IMR Press / FBL / Volume 18 / Issue 2 / DOI: 10.2741/4125

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Experimental models of melatonin-deficient hypertension

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1 Department of Pathophysiology, School of Medicine, Comenius University, Bratislava, Slovak Republic
2 3rd Clinic of Medicine, School of Medicine, Comenius University, Bratislava, Slovak Republic
3 Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
4 Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United States
5 Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic
Front. Biosci. (Landmark Ed) 2013, 18(2), 616–625;
Published: 1 January 2013

Melatonin secreted by the pineal gland plays an important role in the regulation of blood pressure (BP) and its administration reduces hypertension both in animals and humans. There are two experimental models of melatonindeficient hypertension: one induced by pinealectomy and another by continuous 24 hour exposure to light. Both models cause melatonin deficiency and prevent darknessmediated nocturnal melatonin secretion and are associated with increased BP and myocardial, vascular and renal dysfunction. These models also lead to neurohumoral activation of the renin-angiotensin system, sympathetic nervous system, adrenocorticotrophin-glucocorticoid axis and cause insulin resistance. Together, these alterations contribute to rise in blood pressure by vasoconstrictive or circulatory fluid volume overload. The light induced hypertension model mimics the melatonin deficiency in patients with insufficient nocturnal BP decline, in those who have night shift or who are exposed to environmental light pollution. For this reason, this model is useful in development of anti-hypertensive drugs.

Melatonin Deficiency
Continuous Light Exposure
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