IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4109

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Mechanisms of cardioprotection by isoflurane against I/R injury
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1 Department of Cardiology, First Hospital, Shanxi Medical University, Taiyuan Shanxi, P. R. China
2 Department of Psychiatry, First Hospital, Shanxi Medical University, Taiyuan Shanxi, P. R. China
Front. Biosci. (Landmark Ed) 2013, 18(1), 387–393;
Published: 1 January 2013

Myocardial infarction is responsible for most cardiovascular mortality as well as the pathogenesis of myocardial damage during and after infarction. Efforts are underway to modulate the development of ischemia– reperfusion (I–R) injury. Recently, the protective effect of isoflurane against myocardial I–R injury emerged as a possibility. Nitric oxide, nitric oxide synthases, factors related to energy metabolism, adenosine triphosphate- sensitive potassium channels, phosphatidylinositol-3-kinase and hypoxia-inducible factor1-alpha have been shown to participate in the mechanisms of cardioprotection elicited by isoflurane against I–R injury. In this review, we focus on the mechanisms of cardioprotection offered by isoflurane against I–R injury.

Ischemia and reperfusion
HIF 1-alpha
inducible NOS
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