IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4084

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review
Telomere recombination and alternative telomere lengthening mechanisms
Show Less
1 Institut Curie, CNRS UMR3244, UPMC, 26 rue de Ulm, 75005 Paris, France
Academic Editor:Alejandro Bolzan
Front. Biosci. (Landmark Ed) 2013, 18(1), 1–20; https://doi.org/10.2741/4084
Published: 1 January 2013
(This article belongs to the Special Issue Telomeres and telomerase in genome instability)
Abstract

Telomeres are nucleoprotein structures at the ends of linear chromosomes that protect them from being recognized as DNA double stranded breaks. Telomeres shorten with every cell division and in the absence of the checkpoint mechanisms critical telomere shortening leads to chromosome end fusions and genomic instability. Cancer cells achieve immortality by engaging in one of the two known mechanisms for telomere maintenance: elongation by telomerase or through recombination. Recombination based elongation of telomeres, also known as alternative lengthening of telomeres or ALT, is prevalent among cancers of mesenchymal origin. However, the conditions favoring ALT emergence are not known. Here we will discuss possible players in ALT mechanisms, including recruitment of telomeres to recombination centers, alterations of telomere associated proteins and modifications at the level of chromatin that could generate recombination permissive conditions at telomeres.

Keywords
Alternative-Lengthening of Telomeres
ALT
APB
Shelterin
Chromatin
DNA Methylation
Histone Modifications
Review
Share
Back to top