IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4084

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Telomere recombination and alternative telomere lengthening mechanisms
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1 Institut Curie, CNRS UMR3244, UPMC, 26 rue de Ulm, 75005 Paris, France
Front. Biosci. (Landmark Ed) 2013, 18(1), 1–20;
Published: 1 January 2013

Telomeres are nucleoprotein structures at the ends of linear chromosomes that protect them from being recognized as DNA double stranded breaks. Telomeres shorten with every cell division and in the absence of the checkpoint mechanisms critical telomere shortening leads to chromosome end fusions and genomic instability. Cancer cells achieve immortality by engaging in one of the two known mechanisms for telomere maintenance: elongation by telomerase or through recombination. Recombination based elongation of telomeres, also known as alternative lengthening of telomeres or ALT, is prevalent among cancers of mesenchymal origin. However, the conditions favoring ALT emergence are not known. Here we will discuss possible players in ALT mechanisms, including recruitment of telomeres to recombination centers, alterations of telomere associated proteins and modifications at the level of chromatin that could generate recombination permissive conditions at telomeres.

Alternative-Lengthening of Telomeres
DNA Methylation
Histone Modifications
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