IMR Press / FBL / Volume 17 / Issue 7 / DOI: 10.2741/4071

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The origins of vacularization in tumors
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1 Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China
2 Department of Gastroenterology, Changhai Hospital of Second Military Medical University, Shanghai, China
3 Department of Gastroenterology, The First people’s Hospital, Shanghai Jiaotong University, Shanghai, China
Front. Biosci. (Landmark Ed) 2012, 17(7), 2559–2565;
Published: 1 June 2012
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)

Vascularization is crucial for tumor growth and metastasis. Angiogenesis and vasculogenesis are widely accepted processes of tumor vascularization, particularly for endothelium-dependent vessels. In both these processes, the tumor vascular endothelial cells are derived from the host cells, including cells in normal tissues around the tumor or endothelial progenitor cells. In addition, the mosaic vessels occur as a transitional pattern between endothelium-dependent vessels and vasculogenic mimicry (VM), wherein both host endothelium and tumor cells participate in tumor vascularization. VM provides a special passage not involving endothelial cells and is conspicuously different from angiogenesis and vasculogenesis. The biological features of the tumor cells that form VM remain unknown. Tumor stem cells may participate in VM. In this review, we discuss the patterns involved in the origin of vascularization in tumors.

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