IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3931

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Multiple roles of proline transport and metabolism in trypanosomatids
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1 Centre de Resonance Magnetique des Systemes Biologiques, UMR 5536, Universite Bordeaux Segalen, CNRS, Bordeaux, France
2 Wellcome Trust Centre for Molecular Parasitology, The College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
3 Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
Academic Editor:Guoyao Wu
Front. Biosci. (Landmark Ed) 2012, 17(1), 349–374;
Published: 1 January 2012
(This article belongs to the Special Issue Amino acids in nutrition, health, and disease)

Trypanosomatids are a large family of unicellular eukaryotes, many of which are parasites in higher eukaryotes including man. Much of our understanding of metabolism in these organisms has been gained form the study of the human infective representatives (Trypanosoma brucei subpecies, Trypanosoma cruzi and Leishmania spp.) which are transmitted by blood-feeding arthropods. The insect vectors of these parasites use proline as a principal carbon and energy source circulating in their haemolymph. Accordingly the insect-forms of the human infectious parasites have evolved to exploit abundant proline when in this environment, but being able to activate different biochemical pathways when in other environments. Interestingly, if glucose is available, metabolic capability can shift to make this carbohydrate the preferred substrate. Proline has also been shown to play key roles in osmoregulation, differentiation in representatives of the group and may even play a role in immunosuppression elicited by the American trypanosome T. cruzi. This review focuses on recent progress in understanding the different aspects of proline metabolism in trypanosomatids, with a particular interest on the insect forms.

Amino acid homeostasis
Cellular differentiation
Glucose metabolism
Metabolic adaptation
Osmotic stress response
Proline metabolism and transport
Proline racemase
Trypanosoma brucei
Trypanosoma cruzi
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