IMR Press / FBL / Volume 16 / Issue 8 / DOI: 10.2741/3895

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Sources of diversity in T cell epitope discovery
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1 National University of Singapore (NUS), Immunology Programme and Departments of Microbiology and Biological Sciences, Centre for Life Sciences, No 03-05, 28 Medical Drive, 117456, Singapore
2 NUS Graduate School for Integrative Science and Engineering (NGS), Centre for Life Sciences, No 05-01, 28 Medical Drive, 117456, Singapore
3 Singapore–Massachusetts Institute of Technology Alliance (SMA), 4 Engineering Drive 3, 117576, Singapore
4 Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Brenner Centre for Molecular Medicine, 30 Medical Drive, 117609, Singapore
Academic Editor:Darja Kanduc
Front. Biosci. (Landmark Ed) 2011, 16(8), 3014–3035;
Published: 1 June 2011
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)

CD8-positive T cells respond to small antigenic peptide fragments presented on class I major histocompatibility complexes (MHCs). Those specific T cell epitopes capable of precipitating a cellular immune response are either derived from (altered) self (i.e. they are autoimmune- or cancer-associated) or come from foreign sources (i.e. they are pathogen-associated). Identification of T cell epitopes provides elementary information that can be employed in technologies that monitor and predict the likely outcome of an immune response, as well as in therapeutic and vaccine development efforts. The coexistence between host and pathogen has largely driven the diversification of both their systems of immune surveillance and their antigenic determinants, respectively. In this review, we discuss the multitude of factors that introduce diversity to the T cell response from both sides of the host-pathogen interaction. Furthermore, we provide an overview of a variety of commonly employed methods and tools to characterize class I MHC restricted antigen presentation and recent endeavors towards the harmonization of reporting data concerning T cell responses.

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