IMR Press / FBL / Volume 16 / Issue 2 / DOI: 10.2741/3711

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Regulation of VSMC behavior by the cadherin-catenin complex
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1 Bristol Heart Institute, University of Bristol, Research Floor Level Seven, Bristol Royal Infirmary, Upper Maudlin St, Bristol BS2 8HW, United Kingdom
Front. Biosci. (Landmark Ed) 2011, 16(2), 644–657;
Published: 1 January 2011

Vascular smooth muscle cells (VSMCs) are the predominant cell type within blood vessels. In normal vessels VSMC have low rates of proliferation, migration and apoptosis. However, increased VSMC proliferation, migration, and apoptosis rates radically alter the composition and structure of the blood vessel wall and contribute to vascular diseases such as atherosclerosis, in-stent restenosis and vein graft failure. Consequently, therapies that modulate VSMC proliferation, migration and apoptosis may be useful for treating vascular diseases. In this review article we discuss recently emerging research that has revealed that homophilic cell-cell contacts mediated by the cadherin:catenin complex and Wnt/beta-catenin signalling are important regulators of VSMC behaviour.

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