IMR Press / FBL / Volume 16 / Issue 2 / DOI: 10.2741/3709

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Modulation of programmed cell death pathways by the hepatitis C virus
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1 Collaborative Anti-Viral Research Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
2 Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Academic Editor:Maysaa El Sayed Zaki
Front. Biosci. (Landmark Ed) 2011, 16(2), 608–618;
Published: 1 January 2011
(This article belongs to the Special Issue Molecular bases and therapeutic options of hepatitis viruses)

Hepatitis C virus (HCV), a positive stranded RNA virus of the family Flaviviridae, is the major cause of non-A, non-B hepatitis worldwide. The HCV genome encodes a precursor polyprotein of ~ 3,000 amino acids that is processed co-translationally and post-translationally to give rise to viral structural and non-structural proteins. Nearly all of these viral proteins have been shown to modulate cell death via various mechanisms. In addition, studies using the replicon and recombinant HCV cell culture systems have yield important insights into the modulation of programmed cell death by HCV replication. Here, we summarize current knowledge on the modulation of apoptosis and other programmed cell death pathways by the HCV in these cell culture systems.

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