IMR Press / FBL / Volume 16 / Issue 1 / DOI: 10.2741/3671

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Is insulin resistance a disorder of the brain?
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1 Jawaharlal Nehru Technological University, Kakinada 533 003, India.
2 Instituto de Biologia Celular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Barros esquina Gordillo, Cordoba (5000), Argentina
3 CONICET, Argentina
Front. Biosci. (Landmark Ed) 2011, 16(1), 1–12;
Published: 1 January 2011

There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.

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