IMR Press / FBL / Volume 14 / Issue 5 / DOI: 10.2741/3349

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cognitive and limbic effects of deep brain stimulation in preclinical studies
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1 Departments of Neurosurgery and Neuroscience, Maastricht University, Maastricht, The Netherlands
2 Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique, CNRS UMR6155 Aix-Marseille Université, Marseille, France
3 European Graduate School of Neuroscience (EURON), Maastricht, The Netherlands
Front. Biosci. (Landmark Ed) 2009, 14(5), 1891–1901;
Published: 1 January 2009

The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation has generally the same clinical effects as a lesion with respect to the improvement of clinical disability, but has more advantages such as its adjustability and reversibility. To this day, fundamental knowledge regarding the application of electrical currents to deep brain structures is far from complete. Despite improving key symptoms in movement disorders, DBS can be associated with the occurrence of a variety of changes in cognitive and limbic functions both in humans and animals. Furthermore, in psychiatric disorders, DBS is primarily used to evoke cognitive and limbic changes to reduce the psychiatric disability. Preclinical DBS experiments have been carried out to investigate the mechanisms underlying the clinical effects of DBS for at least three (interrelated) reasons: to increase our scientific knowledge, to optimize/refine the technology, or to prevent/reduce side-effects. In this review, we will discuss the limbic and cognitive effects of DBS in preclinical studies.

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