IMR Press / FBL / Volume 14 / Issue 10 / DOI: 10.2741/3505

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy
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1 College of Life Sciences, Wuhan University, Wuhan, China
2 Department of Medicine, Case Western Reserve University, Cleveland, OH
3 Cleveland VAMC Research Service 151, Cleveland, OH
Front. Biosci. (Landmark Ed) 2009, 14(10), 3974–3987;
Published: 1 January 2009

Diabetic retinopathy is the leading cause of blindness and visual disability in the industrialized world. The mechanisms of how diabetic retinopathy develops are still an open question. Alterations contributing to oxidative and nitrosative stress, including elevated nitric oxide (NO) and superoxide production, overexpression of different isoforms of nitric oxide synthase (NOS), nitrated and poly(ADP-ribosy)lated proteins, and downregulation of antioxidative enzymes have been implicated in the pathogenesis of this ocular disease. The possible roles of these components in the development of diabetic retinopathy are reviewed here, and their values as therapeutic targets for inhibiting or delaying the development of diabetic retinopathy are highlighted.

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