IMR Press / FBL / Volume 14 / Issue 10 / DOI: 10.2741/3494

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The synergistic effects of C. Sinensis with CsA in preventing allograft rejection
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1 Department of Renal Transplantation, the First Affiliated Hospital, Medical college of Xi'an Jiaotong University, Xi'an 710061, China
2 Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China

Academic Editor: Jaw-Wen Chen

Front. Biosci. (Landmark Ed) 2009, 14(10), 3864–3871;
Published: 1 January 2009

The severe side-effects of Cyclosporin A (CsA) limited its long term clinical application in allograft recipients. In the present study, we investigated the potential synergistic effects of cordyceps sinensis (Cs) with CsA in an allograft kidney transplant rat model. Cs alone or a low dose of CsA treatment did not prolong graft survival. However, the combined therapy of a low dose of CsA with Cs significantly prolonged graft survival in rats. The allografts showed significantly improved function in a combined therapy in rats as determined by urine volume and serum creatinine levels. Furthermore, significantly less mononuclear cell infiltration in kidney grafts, lower levels of CD4+ T cells in peripheral blood, and less serum IL-2 and IFN-γ Production was observed in recipients treated with combined therapy, as compared with recipients treated with Cs alone or a low dose of CsA. These data indicate that Cs and CsA have synergistic effects to block allogeneic graft rejection, which may be applied in transplant recipients to decrease the dose of CsA and avoid CsA associated side-effects.

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