IMR Press / FBL / Volume 14 / Issue 1 / DOI: 10.2741/3236

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of platelets in acute lung injury (ALI)
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1 La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
2 Department of Anesthesiology and Intensive Care Medicine, University of Munster, Munster, Germany
Academic Editor:Patrick Andre
Front. Biosci. (Landmark Ed) 2009, 14(1), 150–158;
Published: 1 January 2009

Acute lung injury (ALI) is a common syndrome associated with a high mortality rate. Better understanding of the pathophysiology of acute lung injury and progress in supportive care and mechanical ventilation have led to slightly improved clinical outcomes. New evidence shows that the interplay between platelets, leukocytes and endothelial cells is critical in the pathogenesis of ALI. Key molecules involved in this interaction include P-selectin and the eicosanoid thromboxane A2 (TXA2), suggesting potential new targets for pharmacological intervention. In this review, we summarize the aspects of the interactions between platelets, leukocytes, and endothelial cells that are relevant for the pathogenesis of ALI.

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