IMR Press / FBL / Volume 13 / Issue 8 / DOI: 10.2741/2912

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Processing of adeno-associated virus RNA
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1 Department of Molecular Microbiology and Immunology, University of Missouri-Columbia, School of Medicine, Life Sciences Center, Columbia, MO 65212
2 Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160

*Author to whom correspondence should be addressed.


Front. Biosci. (Landmark Ed) 2008, 13(8), 3101–3115;
Published: 1 January 2008

Adeno-associated viruses (AAVs), members of the Dependovirus genus of the subfamily Parvovirinae, family Parvoviridae, have single-stranded DNA genomes that replicate via a double-stranded DNA intermediate which serves as the transcription template. They exhibit a highly compact, overlapping genetic organization which is surprisingly variable amongst various members within the group. Additionally, recent work has shown them to be excellent models for understanding potential interactions between alternative splicing and alternative polyadenylation, the export of unspliced RNAs, and transactivating proteins that influence RNA processing co-transcriptionally via interaction with the transcription template.

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