IMR Press / FBL / Volume 13 / Issue 6 / DOI: 10.2741/2841

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of T-regulatory cells in pregnancy and cancer
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1 Department of Gynecological Surgery, Polish Mother’s Health Center Research Institute, Lodz, Poland
2 3rd Chair and Department of Obstetrics and Gynecology, Medical University, Lodz, Poland
3 Medical and Environmental Pregnancy Health Hazards Unit, Department of Perinatology, 1stChair of Gynecology and Obstetrics, Medical University, Lodz, Poland
4 Department of Surgical and Endoscopic Gynecology, Polish Mother’s Health Center Research Institute, Lodz, Poland

*Author to whom correspondence should be addressed.


Front. Biosci. (Landmark Ed) 2008, 13(6), 2275–2289;
Published: 1 January 2008

The acceptance of paternally-derived alloantigens during pregnancy and escape from host immunosurveillance by cancer are based on similar immunological mechanisms. Among them both natural and peripherally-induced T CD4+CD25+Foxp3+ and Tr1 regulatory cells (Tregs) play important role. Interactions of Tregs with other immunocytes including dendritic cells, mechanisms of Tregs recruitment and their suppressive properties in cancer and pregnancy have been presented in this paper. Despite the fact that mechanisms of Treg regulation are still in progress, there is a hope for use of Tregs-related immunotherapy in clinical practice, and the first attempts of such management have already been described. However, more information about the function of Tregs cells is needed to provide safe treatment devoid of potential side-effects. Resolving the secrets of Tregs cells will probably offer new options of cancer treatment and will help to improve the management of pregnancy failure.

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