IMR Press / FBL / Volume 13 / Issue 6 / DOI: 10.2741/2833

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of dendritic cells in cytotoxic immune response regulation in ovarian cancer micro-environment
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1 1st Department of Gynecology, University School of Medicine, Staszica 16, 20-081 Lublin, Poland

*Author to whom correspondence should be addressed.


Front. Biosci. (Landmark Ed) 2008, 13(6), 2177–2190;
Published: 1 January 2008

Ovarian cancer is the most lethal gynecological malignancy. At the time of diagnosis most patients present with an advanced stage of the disease and require multidisciplinary systemic treatment, including surgery and adjuvant chemotherapy. Despite good initial response to cytostatics, the vast majority of patients develops a recurrence and will need novel therapeutic strategies, as relapsed ovarian cancer is still incurable. One promising treatment option is the use of dendritic cells (DCs) which might induce effective anti-tumor immunity. The ability of DCs to generate an anti-cancer response has been documented in various kinds of human tumors, including malignant melanoma, renal cell carcinoma, and breast cancer tumors. Although DCs were identified in the micro-environment of ovarian cancer, lack of clearly defined ovarian-specific tumor antigens capable of being recognized by T cells is considered the major prohibiting factor in ovarian cancer vaccine development. There is therefore a strong need to identify and employ attractive candidates for tumor-specific antigens. In this review we will focus on current knowledge of the influence of DC mechanisms of cytotoxic T-cell responses and recent advances in DC identification in ovarian cancer patients, in addition to summarizing the data on DC vaccinations in these patients.

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