IMR Press / FBL / Volume 13 / Issue 5 / DOI: 10.2741/2788

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Genetics and development of the optic chiasm
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1 Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez-CSIC, Campus de San Juan, San Juan de Alicante, Alicante 03550, Spain

Academic Editor: Jochen Graw

Front. Biosci. (Landmark Ed) 2008, 13(5), 1646–1653;
Published: 1 January 2008
(This article belongs to the Special Issue Genetics of vision and cognition)

In animals with binocular vision, retinal fibers either project across the midline or they remain on the same side of the ventral diencephalon, forming an X-shaped commissure known as the optic chiasm. The correct formation of the optic chiasm during development is essential to establish a fully functional visual system. Visual dysfunction associated with axonal misrouting at the optic chiasm has been described in albino individuals and in patients with non-decussating retinal-fugal fiber syndrome. Although little is known about the causes of retinal misrouting in these conditions, the molecular mechanisms responsible for the formation of the optic chiasm are beginning to be elucidated in vertebrates. This review focuses on our current knowledge of how the optic chiasm forms, which will hopefully help us to better understand these congenital anomalies.

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