IMR Press / FBL / Volume 13 / Issue 3 / DOI: 10.2741/2755

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Transplantation: current developments and future directions; The future of clinical islet transplantation as a cure for diabetes

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1 Diabetes Research Institute and the Division of Cellular Transplantation, DeWitt Daughtry Family Department of Surgery, University of Miami – Jackson Memorial Hospital Transplant Institute, University of Miami Leonard M. Miller School of Medicine,1450 NW 10th Avenue (R-134), Miami, FL, 33136, USA
Front. Biosci. (Landmark Ed) 2008, 13(3), 1192–1205;
Published: 1 January 2008

Islet transplantation is now a therapeutic option for patients with unstable type 1 diabetes mellitus (T1DM) with hypoglycemic unawareness. The benefits of this treatment include improvement in metabolic control with normalization of A1c and prevention of severe hypoglycemia. Insulin independence and improved quality of life can be reproducibly obtained by transplanting adequate islet numbers. Current obstacles to the widespread application of beta-cell replacement therapies include limited islet availability and the need for chronic immunosuppression. The emergence of promising interventions may be of assistance in improving islet recovery and favoring engraftment of smaller islet masses with comparable or better efficacy. In the future, regenerative efforts will contribute to overcoming this limitation as well. Combining these approaches with the development of safe immune interventions to induce self tolerance or to induce the permanent acceptance of transplanted tissues will be necessary to achieve long-term success. The steady progress and promising results of recent clinical trials justifies a great optimism toward the widespread application of beta-cell replacement as a treatment of choice for patients with diabetes.

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