IMR Press / FBL / Volume 13 / Issue 12 / DOI: 10.2741/3031

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Gene content of LUCA, the last universal common ancestor
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1 Stowers Institute for Medical Research, 1000 E 50th St., Kansas City, Missouri 64110, and Department of Microbiology, Molecular Genetics and Immunology, Kansas University Medical Center, Kansas City, Kansas, 66160, USA

*Author to whom correspondence should be addressed.


Front. Biosci. (Landmark Ed) 2008, 13(12), 4657–4666;
Published: 1 May 2008

Comparative genomics and modern phylogenetic approaches allow us to infer the gene content of LUCA, the Last Universal Common Ancestor of all known currently living cellular organisms. Most of the estimates produce a putative LUCA with 500-1000 protein-coding genes and biochemically coherent metabolism, if the average rates of gene gains (gene emergence plus horizontal gene transfer) and gene losses per family are allowed to be close to each other. This estimate is not strongly sensitive to the topology of the Tree of Life, but the identity of the genes that are placed in LUCA may depend on the position of the deep branches and the root of the tree.

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