IMR Press / FBL / Volume 13 / Issue 1 / DOI: 10.2741/2687

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Biochips: non-conventional strategies for biosensing elements immobilization
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1 Laboratoire de Genie Enzymatique et Biomoleculaire, UMR 5246 ICBMS, CNRS -Universite Claude Bernard Lyon 1, Bat CPE, 43, bd du 11 novembre 1918, 69622 Villeurbanne, Cedex, France
Front. Biosci. (Landmark Ed) 2008, 13(1), 382–400;
Published: 1 January 2008

The present article draws a general picture of non-conventional methods for biomolecules immobilization. The technologies presented are based either on original solid supports or on innovative immobilization processes. Polydimethylsiloxane elastomer will be presented as a popular immobilization support within the biochip developer community. Electro-addressing of biomolecules at the surface of conducting biochips will appear to be an interesting alternative to immobilization processes based on surface functionalization. Finally, bead-assisted biomolecules immobilization will be presented as an open field of research for biochip developments.

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