IMR Press / FBL / Volume 13 / Issue 1 / DOI: 10.2741/2680

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure
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1 University Leipzig, Heart Center Leipzig, Leipzig, Germany

Academic Editor: Ulrik Wisloff

Front. Biosci. (Landmark Ed) 2008, 13(1), 302–311; https://doi.org/10.2741/2680
Published: 1 January 2008
(This article belongs to the Special Issue Exercise in medicine: from basic science to clinical practice)
Abstract

Chronic heart failure (CHF) is a condition characterized by exercise intolerance. The level of activity tolerated by an individual cannot be predicted by classical parameters of left ventricular performance. Therefore, considerable attention has been focused on the role of peripheral factors such as skeletal muscle, which are determinants of work capacity. In recent years, many alterations in the skeletal muscle have been described in patients with chronic heart failure. This knowledge has dramatically changed the treatment of patients with CHF. Previously, patients were asked to avoid excessive strain and physical exercise. Recently, however, patients are asked to participate in a supervised physical training program to increase their exercise capacity and to counteract the molecular changes occurring in the skeletal muscle. This review will focus on molecular and biochemical alterations especially in the skeletal muscle and how these alterations are influenced by exercise training finally contributing to better skeletal muscle performance.

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