IMR Press / FBL / Volume 13 / Issue 1 / DOI: 10.2741/2660

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of toll-like receptors in macrophages
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1 Department of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland

Academic Editor: Angel Lee

Front. Biosci. (Landmark Ed) 2008, 13(1), 62–70;
Published: 1 January 2008
(This article belongs to the Special Issue Biology of the macrophage in human disease)

Macrophages play diverse roles including but not limited to homeostatic clearance, detection of invading pathogens and induction of the adaptive immune response. Since their discovery, it has become clear that Toll-like receptors (TLRs) can play a major role in these macrophage functions. This review will describe the TLRs, their signalling pathways and their role in macrophage function.

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