IMR Press / FBL / Volume 12 / Issue 9 / DOI: 10.2741/2305

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

ABC A-subclass proteins: gatekeepers of cellular phospho- and sphingolipid transport
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1 Institute for Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University Mainz, 55101 Mainz, Germany
2 Department of Clinical Chemistry, Ulleval University Hospital, 0407 Oslo, Norway
3 Institute for Clinical Chemistry, Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
Academic Editor:David Hui
Front. Biosci. (Landmark Ed) 2007, 12(9), 3177–3193;
Published: 1 May 2007
(This article belongs to the Special Issue Lipid and lipoprotein metabolism)

During the past years, available evidence suggests that members of a novel family of structurally highly related multispan proteins, designated ABC A-subclass transporters, exert critical functions in the control of cellular lipid transport processes. Loss-of-function scenarios, thus far, have revealed pivotal roles of individual ABC A-transporters in specialized lipid secretory pathways of the cell including HDL biogenesis (ABCA1), lung surfactant production (ABCA3), retinal integrity (ABCA4/ABCR) and skin lipid barrier formation (ABCA12). Although the specific transporter activities of many members of this novel protein family have not yet been established in detail, available evidence indicates that ABC A-subclass transporters function as key components of highly specialized cellular phospho- and sphingolipid export machineries in major physiologic systems.

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