IMR Press / FBL / Volume 12 / Issue 8 / DOI: 10.2741/2282

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Mechanisms of tolerance induced via mixed chimerism
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1 Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Academic Editor:Gilles Benichou
Front. Biosci. (Landmark Ed) 2007, 12(8), 2922–2934;
Published: 1 May 2007
(This article belongs to the Special Issue New insights in transplantation tolerance)

Mixed hematopoietic chimerism provides a powerful means of inducing robust, donor-specific tolerance. In this article, the minimal requirements for achieving mixed chimerism, the development of new reagents that promote its achievement, and the mechanisms by which peripheral and intrathymic tolerance are achieved via mixed chimerism are discussed. An emerging understanding of these mechanisms, along with the development of new immunosuppressive reagents, is allowing advancement toward clinical application of this approach.

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