IMR Press / FBL / Volume 12 / Issue 7 / DOI: 10.2741/2416

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction
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1 Division of Cardiology, Scott and White Memorial Hospital, Scott, Sherwood and Brindley Foundation and Cardiovascular Research Institute, Division of Molecular Cardiology, Texas A and M University System, Health Science Center College of Medicine, Temple, TX, USA
2 Division of Cardiology, Scott and White Memorial Hospital, Scott, Sherwood and Brindley Foundation, USA
3 Cardiovascular Research Institute, Division of Molecular Cardiology, Texas A and M University System, Health Science Center College of Medicine, Temple, TX, USA
4 Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA
5 Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infections Diseases, Bethesda, MD, USA
6 Scott and White Cancer Research Institute, Temple, TX, USA
Front. Biosci. (Landmark Ed) 2007, 12(7), 4670–4675; https://doi.org/10.2741/2416
Published: 1 May 2007
Abstract

Fatalities due to anthrax are associated with severe hypotension suggesting that the toxins generated from Bacillus anthracis, lethal toxin (LeTx) and edema toxin (EdTx), have cardiovascular effects. Here, we demonstrate the effects of these toxins and characterize their effects by echocardiography. LeTx leads to a significant reduction in ejection fraction, decreased velocity of propagation (diastolic dysfunction), decreased velocity of circumferential fiber shortening (decreased contractility), and increased LV systolic area (pathophysiology). EdTx leads to a significant reduction in left ventricular volumes and cardiac output (reduced stroke volume) but does not cause significant change in ejection fraction or contractility. These results indicate that LeTx reduces left ventricular systolic function and EdTx reduces preload but does not have direct myocardial effects. Together, these findings suggest that LeTx and EdTx exert distinct hemodynamic dysfunction associated with anthrax infection.

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