IMR Press / FBL / Volume 12 / Issue 7 / DOI: 10.2741/2406

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Alpha-melanocyte stimulating hormone peptide-targeted melanoma imaging
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1 College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
2 Department of Biochemistry, Columbia, MO 65211, USA
3 Department of Radiology, University of Missouri, Columbia, MO 65211, USA
4 Harry S. Truman Memorial Veteran Hospital, Columbia, MO 65201, USA
Academic Editor:Xiaoyuan Chen
Front. Biosci. (Landmark Ed) 2007, 12(7), 4514–4524;
Published: 1 May 2007
(This article belongs to the Special Issue Molecular imaging of biomarkers)

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target over-expressed on the surface of melanoma cells. Alpha-melanocyte stimulating hormone (alpha-MSH) peptide analogues can specifically bind MC1 receptors with nanomolar binding affinities, making alpha-MSH peptide analogues very promising candidates for developing effective melanoma-specific imaging probes. This review highlights the strategies being used to design alpha-MSH peptide radiopharmaceuticals to target MC1 receptors and some recent developments of radiolabeled alpha-MSH peptide analogues for melanoma imaging.

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