IMR Press / FBL / Volume 12 / Issue 6 / DOI: 10.2741/2225

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Gene expression profiling of early involuting mammary gland reveals novel genes potentially relevant to human breast cancer
Show Less
1 Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
2 Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
3 Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
4 Division of Host Genetics and Prion Diseases, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada
5 Emory University Eye Center, Atlanta, GA, USA
Front. Biosci. (Landmark Ed) 2007, 12(6), 2221–2232;
Published: 1 January 2007

Mammary gland involution represents one of the most dramatic examples of programmed cell death/apoptosis and tissue regression during development, yet large gaps still exist in the understanding of the mechanisms involved, and the key factors that trigger involution, are not yet identified. With the focus on identifying "novel" genes associated with mammary gland regression, we used microarray analysis to examine differentially expressed genes during early mammary gland involution in the mouse. We then examined the relevance of candidate genes to human tumorigenesis and identified a number of genes not previously implicated or not well characterized in human breast cancer. The expression levels of these genes in human breast cancer were confirmed in breast cancer cell lines and breast tumor tissues. This pilot study demonstrates proof of principle that through the analysis of gene expression during mammary gland involution, it may be possible to identify "novel" genes relevant human breast cancer.

Back to top