IMR Press / FBL / Volume 12 / Issue 6 / DOI: 10.2741/2214

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Tracing complement-retroviral interactions from mucosal surfaces to the lymphatic tissue
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1 Department of Hygiene, Microbiology and Social Medicine and Ludwig Boltzmann Institute for AIDS Research, Innsbruck Medical University, Austria
Academic Editor:Heribert Stoiber
Front. Biosci. (Landmark Ed) 2007, 12(6), 2096–2106;
Published: 1 January 2007
(This article belongs to the Special Issue Immune responses to retroviral infections)

During (nearly) all steps in retroviral pathogenesis, viruses are confronted with complement and complement receptor (CR)-positive cells. As all of the retroviruses tested so far activate the complement system, members of this virus family have adapted different protection mechanisms to keep complement activation under the threshold necessary to avoid complement-mediated lysis. As a consequence of complement activation, retroviruses are covered with complement proteins and thus provide additional ligands to interact with CR-expressing cells. This review discusses the complex complement-retroviral interactions and follows the fate of the virus on its way to the lymphatic tissue.

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