IMR Press / FBL / Volume 12 / Issue 5 / DOI: 10.2741/2190

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Multisite phosphorylation of the cAMP response element-binding protein (CREB) by a diversity of protein kinases
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1 Faculty of Medicine, Department of Microbiology and Virology, University of Tromso, N-9037 Tromso, Norway
Front. Biosci. (Landmark Ed) 2007, 12(5), 1814–1832;
Published: 1 January 2007

The prevailing view of stimulus-induced activation of the transcription factor cAMP response element-binding protein (CREB) presumes phosphorylation at serine-133. Although, phosphorylation of this residue seems to be necessary, it is not sufficient to trigger CREB-driven transcription, indicating that other phosphoserine-133-independent mechanisms are required for full activation of CREB. One of these additional regulatory mechanisms influencing the transcriptional state of CREB may involve multiple phosphorylation events on other phosphoacceptor sites in the protein. This review focuses on the phosphorylation modifications of CREB by distinct protein kinases and discusses the possible implications for the function of CREB.

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