IMR Press / FBL / Volume 12 / Issue 4 / DOI: 10.2741/2169

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Mapping the future of common diseases: lessons from psoriasis
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1 Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Italy
2 Department of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas,72205, USA
3 San Peter Hospital, Fatebenefratelli, Rome, Italy
Front. Biosci. (Landmark Ed) 2007, 12(4), 1563–1573;
Published: 1 January 2007

Psoriasis (OMIM*177900) is a common, chronic, hyperproliferative inflammatory disorder of the skin affecting approximately 2% of Caucasians. Despite the prevalence of psoriasis in general population, significant differences in the incidence among Japanese, Eskimos, West Africans, north American blacks and American natives are well known. The cause for these variations are likely to be both genetic and environmental. Independent genomewide scans have suggested the involvement of a large number of chromosomal regions (loci), but so far only poor susceptibility genes have been suggested. We discuss genetic basis of the disease, results and interpretations of relevant studies, with particular regard to study design and future perspectives. Indeed to date, mapping genes which contribute to complex diseases is one of the major challenge in the post-genomic era.

"But remember throughout that no cause is efficient without a predisposition of the body itself, otherwise, external factors which affect one would affect all." (Galen, 130-200 CE)

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