IMR Press / FBL / Volume 12 / Issue 3 / DOI: 10.2741/2134

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Role of nitric oxide on mitochondrial biogenesis during the ovarian cycle
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1 Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
2 Department of Obstetric and Gynecology, Hospital de Jerez de la Frontera, University of Cadiz, Spain
Academic Editors:Alberto Boveris, Ana Navarro
Front. Biosci. (Landmark Ed) 2007, 12(3), 1164–1173; https://doi.org/10.2741/2134
Published: 1 January 2007
(This article belongs to the Special Issue Mitochondria: physiological function, signaling and oxidative damage)
Abstract

The mitochondrial changes in the ovary during the ovarian cycle are adapted to a cyclically increased-decreased energy demand. In the proliferative phase, the increased energy needs are sustained by the recruitment of mitochondria in active state 3, by an increased tissue O2 consumption and ATP production and by an increase in the number of mitochondria. In the phase of decreased energy needs, mitochondria-dependent apoptosis reduces tissue and mitochondrial O2 uptake. The ovary morphological changes during the cycle describe a process in which the follicles undergo a clear cycle with two sequential phases: proliferation and apoptosis. The follicular growth stimulated by FSH characterizes a tissue that shows a quick cell proliferation. During the ovarian cycle, tissue and mitochondrial O2 uptakes, mitochondrial mass, mitochondrial NO production and cytochrome oxidase activity exhibit a biphasic pattern, with marked increases in the ovary proliferative phases. Relatively low levels of NO seem to drive the cell signaling for follicle proliferation, whereas relatively high NO levels trigger mitochondria-dependent follicle apoptosis.

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