IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2389

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Macrophages and the hypoxic tumour microenvironment
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1 Nuffield Department of Orthopaedic Surgery, Botnar Research Centre, University of Oxford, OX3 7LD , UK
2 Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 7NG, UK
Academic Editor:Angel Lee
Front. Biosci. (Landmark Ed) 2007, 12(11), 4298–4314; https://doi.org/10.2741/2389
Published: 1 May 2007
(This article belongs to the Special Issue Biology of the macrophage in human disease)
Abstract

One characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we will discuss the molecular mechanisms that underlie recruitment of macrophages into tumours and their pro-tumourigenic activities with respect to stimulation of angiogenesis, lymphangiogenesis, tumour cell migration, metastasis and immuno-suppression. The potential of macrophage-related anticancer therapies will be discussed in the light of this phenotype.

Keywords
Tumour-associated macrophage
TAM
Angiogenesis
Hypoxia
Immunosuppression
Migration
Metastasis
therapy
Review
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